Best Vyse Setups On Ascent

Written by: Wei

12/02/2025

Vyse is one of the newer agents in the game, although she has been out for a while it’s still rare to see someone utilizing her to her maximum capability. In this guide, we will show you how to use Vyse, with creative defending and attacking setups.

Yes, attacking too, we will show you where to use your abilities when you attack, as she can be very overpowered on both sides. So let’s start shall we? Here’s the best guide for Vyse on Ascent:

Defending Side

vyse_ascent_defend_a

This setup is your win card if enemies decide to push A. It covers all the necessary spots and gives you a solid defense line.

Place your thorns on default to block enemy duelist dashes or to delay plant

Angle your wall so it is not easy to bait with a jump peek or omen fake TP

Finally place your flash high up on heaven and activate it whenever you see fit.

vyse_ascent_defend_b

This setup on B is the classical killjoy cosplay you can do to lockdown site. It is strong and tested in higher ranked lobbies.

Place your wall on lane to block enemies from pushing all at once.

Put your thorns right in front of the wall, so you can isolate the passed enemy and win the fight

Have your flash placed angled to lane very high on the wall, easy kills!

Attacking Side

vyse_ascent_attack_a

When attacking you might not think you have a lot of value to give to the team, but in fact, you do! Here’s how:

Place your wall for flank, this way you know if it got triggered

Have your flash go high through the wall (left side) and time it with your duelist’s entry

Place your thorns on default or wherever the spike is, as you want to use it for post plant situations.

vyse_ascent_attack_b

Lastly on B, here’s how you can make sure your duelists are going to have an easy time entering site:

Place your wall for flank, as always, you should do that in attacking halves.

Place your flash through the left wall and activate it as you execute site

Throw your thorns on market and activate it instantly, this allows you to block enemies from walking out of there when you’re pushing.

Pro Tips

Vyse’s wall is a very versatile ability. It’s not just used to defend a site, but also to detect flanks on the attacking side. When you place the wall, it will alert you if anyone walks through, working like a perfect Cypher trip.
Your flash can be placed through walls. So even through a thicker wall you could still place it and use it. Although it has a little bit of time before it activates so you will not be able to use it as a fast paced flash.
Remember that your abilities can still deal damage to you, so make sure you understand Vyse’s mechanics to not get caught off guard from your own abilities.
Enemies can still move through your thorns (Molly) if they shift (walk) so make sure you are aware of that. It will make no sound if enemies are just walking through your molly.
Because your flash is made to be set up, you can use the flash with your gun out which makes it incredibly powerful especially when you’re defending a site. Use that to your advantage.
Your ultimate blocks enemies from using primary weapons. But they can still use pistols and ultimates, so beware from a Jett or an ulted Chamber that will peek you after your ability has hit them.
Try to not waste your abilities on attack until you’ve secured a plant on site. As before, it is difficult for you to get value without lurking. As a Vyse, you should lurk or set up for post plant with your abilities on the attacking side.