Best Vyse Setups On Split

Written by: Wei

12/02/2025

Vyse is one of the newer agents in the game, although she has been out for a while it’s still rare to see someone utilizing her to her maximum capability. In this guide, we will show you how to use Vyse, with creative defending and attacking setups.

Yes, attacking too, we will show you where to use your abilities when you attack, as she can be very overpowered on both sides. So let’s start shall we? Here’s the best guide for Vyse on Split:

Defending Side

vyse_split_defense_a

A site is hard to defend on Split, especially if enemies know what they’re doing. Although with this setup, they won’t know what to do:

Place your wall and thorns on A main as shown in the picture, this is so you isolate and deal damage to the enemy team

Have your flash in front of site high up on the wall, activate it when enemies push

vyse_split_defense_b

Going over to B, it is important that you play in a safe position as in the picture, if you stay any closer, enemies can get to you mush faster.

Place your wall for B main

Have your thorns activate on mid site if enemies trigger the wall (and you know it isn’t a wall bait)

Then finally your flash should be high on B site like a cypher cam, activate it when you’re taking a fight.

Attacking Side

vyse_split_attack_a

On A’s attacking side, you want to utilize yourself best so you can take full site control, here’s how to do it:

Throw your thorns on A Ramp to prevent enemies from peeking you as you push

Place your wall behind to prevent any flankers

Finally flash through the wall going onto A site. If you can’t place this flash from A main, do it by walking a little forward.

vyse_split_attack_b

Lastly on B, you want to be aggressive because you can as a Vyse initiate or help initiate the execute on this site.

Place your flash through the wall, you can determine how much to the left or right you want it to be

Have your wall watch flank (yes, it’s like your little trip in the attacking side)

Finally throw your thorns on default. You can do so early on the round to fight off anyone in that position or to use it as a post plant scenario.

Pro Tips

Vyse’s wall is a very versatile ability. It’s not just used to defend a site, but also to detect flanks on the attacking side. When you place the wall, it will alert you if anyone walks through, working like a perfect Cypher trip.
Your flash can be placed through walls. So even through a thicker wall you could still place it and use it. Although it has a little bit of time before it activates so you will not be able to use it as a fast paced flash.
Remember that your abilities can still deal damage to you, so make sure you understand Vyse’s mechanics to not get caught off guard from your own abilities.
Enemies can still move through your thorns (Molly) if they shift (walk) so make sure you are aware of that. It will make no sound if enemies are just walking through your molly.
Because your flash is made to be set up, you can use the flash with your gun out which makes it incredibly powerful especially when you’re defending a site. Use that to your advantage.
Your ultimate blocks enemies from using primary weapons. But they can still use pistols and ultimates, so beware from a Jett or an ulted Chamber that will peek you after your ability has hit them.
Try to not waste your abilities on attack until you’ve secured a plant on site. As before, it is difficult for you to get value without lurking. As a Vyse, you should lurk or set up for post plant with your abilities on the attacking side.