Best Vyse Setups On Lotus

Written by: Wei

12/02/2025

Vyse is one of the newer agents in the game, although she has been out for a while it’s still rare to see someone utilizing her to her maximum capability. In this guide, we will show you how to use Vyse, with creative defending and attacking setups.

Yes, attacking too, we will show you where to use your abilities when you attack, as she can be very overpowered on both sides. So let’s start shall we? Here’s the best guide for Vyse on Lotus:

Defending Side

vyse_lotus_defense_a

This setup is lethal to anyone trying to push A. While this may not be your favorited site to hold, it is still a great option:

Place your wall and thorns on A main. This prevents many enemies from crossing and deals damage to the one who does

Place your flash through the wall on tree, when enemies open door and step, flash it and peek

vyse_lotus_defense_b

B is a very narrow space, but you can use that to your advantage. Here’s how:

Place your wall right on the choke point to isolate enemies

Place your flash through the wall from C link

Finally place your thorns on default, or where you think enemies will try to plant

vyse_lotus_defense_c

Lastly on C, this is where you’ll shine. Your prime time and position:

Place your wall on the choke point, preventing enemies from pushing at once

Place your thorns right in front of bend, giving you space to fight. Add to it your flash from behind, activate and peek, easy kills!

Attacking Side

vyse_lotus_attack_a

This lineup is perfect for A as it will walk you through the process of entering and playing proper post plant:

Place your wall on flank, disallowing anyone from walking past A lobby without you knowing

Help your team enter through a wall flash on tree

Finally use your thorns for post plant in case you needed to activate to fight off the defuse

vyse_lotus_attack_c
Lastly, here's how you can utilize Vyse best on Lotus:

Place your wall on flank, ensuring nobody can walk past C lobby

Throw your thorns on water, this prevents defenders from retaking site easily

Use your flash either on Bend for your duelist, or high on the wall to flash site for yourself/team

Pro Tips

Vyse’s wall is a very versatile ability. It’s not just used to defend a site, but also to detect flanks on the attacking side. When you place the wall, it will alert you if anyone walks through, working like a perfect Cypher trip.
Your flash can be placed through walls. So even through a thicker wall you could still place it and use it. Although it has a little bit of time before it activates so you will not be able to use it as a fast paced flash.
Remember that your abilities can still deal damage to you, so make sure you understand Vyse’s mechanics to not get caught off guard from your own abilities.
Enemies can still move through your thorns (Molly) if they shift (walk) so make sure you are aware of that. It will make no sound if enemies are just walking through your molly.
Because your flash is made to be set up, you can use the flash with your gun out which makes it incredibly powerful especially when you’re defending a site. Use that to your advantage.
Your ultimate blocks enemies from using primary weapons. But they can still use pistols and ultimates, so beware from a Jett or an ulted Chamber that will peek you after your ability has hit them.
Try to not waste your abilities on attack until you’ve secured a plant on site. As before, it is difficult for you to get value without lurking. As a Vyse, you should lurk or set up for post plant with your abilities on the attacking side.